The variable region of these antibodies bind to allergic antigen, for example house dust mite particles, while its Fc region (in the ε heavy chains) binds ...

We have derived cDNA clones from two hybridomas making NP b antibodies. One, B1–8, made an IgM protein and was derived during a primary response.

The amino-terminal variable or V domains of the heavy and light chains (VH and VL, respectively) together make up the V region of the antibody and confer on it ...

A rapid and generally applicable method for the modification of immunoglobulin cDNAs was developed so that the variable (V) regions could be expressed as ...

This region of the antibody is called the Fab (fragment, antigen binding) region. It is composed of one constant and one variable domain from each heavy and ...

To examine germ line genes of the heavy chain variable region (VH) that might contribute to formation of antibodies of the NPb family, we have derived cDNA ...

Here we review recent research activity in variable region engineering to generate superior antibody therapeutics.

The top of the Y shape contains the variable region (V), also known as the fragment antigen-binding (F(ab)) region. This region binds tightly to a specific part ...

An empirical model relating variable region (Fv) charge and hydrophobicity to cyno nonspecific clearance was developed to gauge the risk an antibody would have ...

Jun 15, 2017 ... Here we present the first study to investigate the effect of removing the constant regions from antibodies and T-cell receptors on such simulations.